Painless Science Projects (Barron's Painless Series)
Affiliations 1. No matching affiliation detected. Find all citations in this journal default. Or filter your current search. Cell [01 Apr , 2 ]. Type: Research Support, U. Gov't, P.
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Gov't, Research Support, U. Gov't, Non-P. Abstract We describe a paradigm for nociception in Drosophila. In response to the touch of a probe heated above 38 degrees C, Drosophila larvae produce a stereotypical rolling behavior, unlike the response to an unheated probe. In a genetic screen for mutants defective in this noxious heat response, we identified the painless gene. Recordings from wild-type larval nerves identified neurons that initiated strong spiking above 38 degrees C, and this activity was absent in the painless mutant.
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The painless mRNA encodes a protein of the transient receptor potential ion channel family. Painless is required for both thermal and mechanical nociception, but not for sensing light touch. An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling. Seller: Neptun Trading. Seller: Online World Books.
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Painless Life Science (Barron's Painless)
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- Behavioral Aversion to AITC Requires Both Painless and dTRPA1 in Drosophila?
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Publisher Barron's Educational Series. Publication date February 1, Language English.
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